Do NSAIDS cause miscarriage?

Do NSAIDS cause miscarriage?

Postby MamaBee » Mon Apr 06, 2015 2:53 pm

The research seems to be conflicting.

In 2011 the Canadian Medical Association Journal published this: "The risk of miscarriage is 2.4 times greater for women who took any type and dosage of nonaspirin nonsteroidal anti-inflammatory drugs (NSAIDs) in early pregnancy, according to a study in CMAJ(Canadian Medical Association Journal)."

Link: http://www.cmaj.ca/site/misc/pr/6sept11_pr.xhtml

Three years later in 2014 the same journal published another study that directly denied the first.
"Women who take nonsteroidal anti-inflammatory drugs (NSAIDs) during pregnancy are not at increased risk of miscarriages, confirms a new study published in CMAJ (Canadian Medical Association Journal)."

Link: http://www.cmaj.ca/site/misc/pr/3feb14_pr.xhtml

On a personal note, I took Advil (Ibuprofen) multiple times during this last pregnancy that ended in miscarriage. I do not usually take these kinds of medications but I did this time due to headaches and a case of the flu. Maybe the headaches were caused by the abnormal pregnancy but I don't know. There is enough question that I am going to avoid the NSAIDS if I am ever pregnant again.

One theory is that these drugs affect the levels of prostaglandins which may cause an unhealthy fluctuation in the uterus.

What do you think? Are NSAIDS safe in pregnancy?

Note:
This study was done in Canada where women must get a prescription for these drugs. It would be hard to get a clear picture in the US because many NSAIDS are over the counter and miscarriages often go unreported.
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